Structure and Function of Kv4-Family Transient Potassium Channels
نویسندگان
چکیده
منابع مشابه
Structure and function of Kv4-family transient potassium channels.
Shal-type (Kv4.x) K(+) channels are expressed in a variety of tissue, with particularly high levels in the brain and heart. These channels are the primary subunits that contribute to transient, voltage-dependent K(+) currents in the nervous system (A currents) and the heart (transient outward current). Recent studies have revealed an enormous degree of complexity in the regulation of these chan...
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Kv4 channels represent the main class of brain A-type K+ channels that operate in the subthreshold range of membrane potentials (Serodio, P., E. Vega-Saenz de Miera, and B. Rudy. 1996. J. Neurophysiol. 75:2174- 2179), and their function depends critically on inactivation gating. A previous study suggested that the cytoplasmic NH2- and COOH-terminal domains of Kv4.1 channels act in concert to de...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2004
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00039.2003